Correlated mutations select misfolded from properly folded proteins
نویسندگان
چکیده
منابع مشابه
Thermodynamic stability of folded proteins against mutations
By balancing the average energy gap with its typical change due to mutations for protein-like heteropolymers with M residues, we show that native states are unstable to mutations on a scale M ∼ (λ/σμ) 1/ζs , where λ is the dispersion in the interaction free energies and σμ their typical change. Theoretical bounds and numerical estimates (based on complete enumeration on four lattices) of the in...
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MOTIVATION Prediction of disulfide bond connectivity facilitates structural and functional annotation of proteins. Previous studies suggest that cysteines of a disulfide bond mutate in a correlated manner. RESULTS We developed a method that analyzes correlated mutation patterns in multiple sequence alignments in order to predict disulfide bond connectivity. Proteins with known experimental st...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2017
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btx013